Family finds comfort after image of man killed appears outside ...

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BURLINGTON -- The family of a North Carolina man killed last month says a miracle image is helping them heal. Kevette Jones, 22, was killed in a shooting outside his Burlington home last month. His family says days later they found his face watching over them.

Lydia Jones says her son Kevette was a miracle baby.

"I went to Chapel Hill for years to the fertility clinic and they said I couldn't have a child," said Jones.

On the evening of Oct. 23, the 22-year-old was sitting on his front steps with friends, when his girlfriend, Savanna Matias, says two men showed up at the home. She says a conversation over a friend escalated to shots fired.

"They took my baby and see they gotta deal with that because that's the law of this land, but in the spirit realm, I have to forgive them. Cause I want to see heaven," said Jones.

The family has found some comfort on the street ouside their home and they're calling it an act of God. They say they see the image of Jones looking down on them from a power transformer on a utility pole. Savanna was the first to spot it.

"I was just sitting right here and you look up and you saw it and it looks just like him--his dreads, his eyes and his nose and his mouth," she said.

"That's my baby watching over me," said Jones. "It's gotta be something that God wants us to understand."

The family explains the image is best seen at night and it's giving them hope in the wake of the horror.

"One of his friends said that he prayed and asked God to show him a sign that Kevette was alright and once Savanna showed him that figure, he said he felt better," said Jones. "God gave us a miracle."

Police arrested two Durham men in connection to the shootings. Marquis Spence, 22, and Brandon Malone, 22, are charged with first-degree murder.

Source: http://triad.news14.com/content/top_stories/668640/family-finds-comfort-after-image-of-man-killed-appears-outside-burlington-home

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iPad Mini Teardown: Tiny Screws, Lots of Adhesive

The iPad mini isn't even officially on sale yet, but iFixit managed to get its hands on one to tear it apart and see how it ticks.

Source: http://feedproxy.google.com/~r/GearFactor/~3/6_ChR9oeb2Q/

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George Lucas Prepares To Launch A 'Bill Gates-Style Philanthropic ...

On Tuesday, George Lucas announced Disney purchased his Lucasfilm production company for a whopping $4 billion.

But don't expect Lucas to make any extravagant purchases in the immediate future.

Instead, the creator of the "Star Wars" franchise has plans for a major "Bill Gates-style philanthropic initiative" focusing on education and health issues, according to The Hollywood Reporter.

But Lucas is no stranger to charitable giving, as he currently serves as chairman of the George Lucas Educational Foundation and in 2006 gave $175 million to his alma mater, USC. He also supports charities such as Make-A-Wish, Stand Up To Cancer, Film Foundation, among others.

In September, even before the new Disney deal, Forbes estimated the divorced, 68-year-old filmmaker's net worth at $3.3 billion, making him the 36th richest celebrity in the world.

In 2010, Lucas signed The Giving Pledge, the effort by Gates and Warren Buffett to get America's wealthiest individuals and families "to commit to giving the majority of their wealth to the philanthropic causes and charitable organizations of their choice either during their lifetime or after their death."

"I am dedicating the majority of my wealth to improving education," explained Lucas in a public letter at the time of the pledge. "It is the key to the survival of the human race. We have to plan for our collective future -- and the first step begins with the social, emotional and intellectual tools we provide to our children."

Read the rest of the letter below in which Lucas explains his philanthropic beliefs and future plans (via GivingPledge.org):

Storytellers are teachers and communicators who speak a universal language.? That was Homer?s primary role, and both Plato and Aristotle used narratives and dialogues as a means of educating.? Good storytelling is based on truths and insights, and a good storyteller is ultimately a teacher ? using the arts as a means of making education emotionally meaningful.? These are all tools at our educational system?s disposal, but too often we aren?t making use of them.

When I was in high school, I felt like I was in a vacuum, biding time.? I was curious, but bored.? It was not an atmosphere conducive to learning.? I was fortunate that I found my path and my language.?

It?s scary to think of our education system as little better than an assembly line with producing diplomas as its only goal.? Once I had the means to effect change in this arena, it became my passion to do so ? to promote active, life-long learning.? I believe in the artisan school of learning, through apprenticeships and Aristotelian questions and discussion.? This level of engagement dates back to the beginning of human life, but it?s still the best way of doing things.? There have to be universal standards ? particularly in education ? and while it seems unwieldy, there is a willingness among educators to share their best practices.

Ultimately, that is why I created Edutopia and the George Lucas Educational Foundation.

The focus of GLEF has been to share educational innovations ? cooperative and project learning, mentorship, parental involvement, and technological advances.? This all comes straight from those on the front lines, from teachers who are putting these methods into practice.? We are the facilitators.? Our goal has been to showcase bold successes and inspire others to further increase the appetite for education.? Our hope is that administrators, teachers, and parents will see the power of these collective efforts and join the fight for wider reforms.

But reform is just the beginning.? We need to build new foundations, fostering independent thought and a desire to keep learning.? Our students need to come away with more than just survival skills, and more than just what is required to complete the program.? We need to promote critical thinking and emotional intelligence.? We need to focus on building an education system that promotes different types of learning, different types of development, and different types of assessment.? We have an opportunity and an obligation to prepare our children for the real world, for dealing with others in practical, project-based environments.? It?s about working together and building character ? being compassionate, empathetic, and civil as a means to a greater end.

As technology changes, so do students.? So should classrooms, and so should our methods of teaching.? In a few short years, connectivity has gone from a technological novelty to a daily necessity.? It?s how our culture communicates, and our children are at the forefront of its use.? Understanding those tools ? and how to integrate them into learning ? is an integral step in defining our future. ?

My pledge is to the process; as long as I have the resources at my disposal, I will seek to raise the bar for future generations of students of all ages.

I am dedicating the majority of my wealth to improving education.? It is the key to the survival of the human race.? We have to plan for our collective future ? and the first step begins with the social, emotional, and intellectual tools we provide to our children.? As humans, our greatest tool for survival is our ability to think and to adapt ? as educators, storytellers, and communicators our responsibility is to continue to do so.

George Lucas

SEE ALSO: A new Star Wars is coming in 2015 >

Source: http://www.businessinsider.com/heres-what-george-lucas-is-going-to-do-with-his-new-billions-2012-10

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Bullying has long-term health consequences

ScienceDaily (Oct. 30, 2012) ? Childhood bullying can lead to long term health consequences, including general and mental health issues, behavioral problems, eating disorders, smoking, alcohol use, and homelessness, a study by the Crime Victims' Institute at Sam Houston State University found.

"What is apparent from these results is that bullying victimization that occurs early in life may have significant and substantial consequences for those victims later in life," said Leana Bouffard, Director of the Crime Victims' Institute. "Thus, the adverse health consequences of victimization are much more far-reaching than just immediate injury or trauma. Understanding these long term consequences is important to assessing the true toll of crime on its victims and on society as well as responding to victims more effectively."

The study, "The Long Term Health Consequences of Bullying Victimization," recommends investing in victim services and effective prevention programs, such as the Olweus Bullying Prevention Program, a school based initiative for violence prevention. Programs can help address the immediate trauma, both mental and physical, that victims experience.

"This type of investment may also have the added benefit of reducing the long-term deleterious effects identified in this and other studies, thus reducing the high cost of victimization born by the victims themselves, the health care system and society in general," Bouffard said.

The current study is based on the National Longitudinal Survey of Youth, a long term study that tracks a sample of U.S. residents born between 1980 and 1984. Nineteen percent of those surveyed said they had been a victim of repeated bullying.

The study found that those bullying victims had more negative perceptions of their general health and mental health and higher rates of emotional/mental or behavioral problems that interfered with school or work. They were also more likely to have an eating disorder, smoke, consume alcohol, experience subsequent violent victimization, or be homeless.

"While these are adverse consequences themselves, they may also serve as intermediate mechanism for even more long-term health issues, such as cancer, alcoholism, depression and other serious problems," said Maria Koeppel, co-author of the study.

Full report; http://www.crimevictimsinstitute.org/publications/?mode=view&item=32

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The above story is reprinted from materials provided by Sam Houston State University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/RjbRdo4Bv0s/121030210533.htm

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Smith almost perfect, 49ers flatten Arizona 24-3

GLENDALE, Ariz. (AP) ? Three touchdown passes, one incomplete pass.

Not a bad night for Alex Smith, and it could have been better, considering that the one incomplete pass was dropped by a wide-open receiver.

The San Francisco quarterback completed 18 of 19 passes for 232 yards and three touchdowns ? two to Michael Crabtree and one to Randy Moss ? to help San Francisco flatten the Arizona Cardinals 24-3 on Monday night.

"Eighteen of 19, I have never seen that," 49ers coach Jim Harbaugh said. "How important for your quarterback to play very well? It is very important and I don't know how you play much better. It was a fantastic game by him."

Arizona defensive tackle Darnell Dockett could hardly believe what Smith had done.

"Everyone's surprised. My 5-year-old son's surprised," Dockett said, "but at the end of the day it wasn't like he had to make the long perfect throws. He had some guys open and we missed some tackles and they made plays."

Smith said he had no idea his stats were that good.

"Which is a good thing," he said. "I don't want to think about my stats or incompletions or anything like that. I was kind of in a good rhythm, the whole offense was. "

Smith has withstood more than his share of criticism he was the No. 1 overall pick in the draft in 2005. He was not interested in calling this a statement performance.

"At this point I don't care," he said. "if you ask me a few years ago, yeah maybe, but at this point I don't really care. I am concerned about winning. The guys in the locker room know what I am about and that is what really matters."

As for reports he had lost his confidence, Smith said, "It was in my closet. I found it."

Smith was 14 of 15 for 146 yards and two touchdowns, both to Crabtree, as the 49ers built a 17-0 halftime lead.

Moss caught a 47-yard TD pass, dodging tacklers down the sideline on a play that seemed to turn back the clock to the receiver's prime. With the catch, he tied Terrell Owens for fourth on the NFL career touchdown list with 156.

Smith, who tied a career high with the three touchdown passes, spread out his completions to 10 receivers. Crabtree led the way with five catches for 72 yards.

Arizona's defense, supposed to be the team's strength, missed tackle after tackle in an embarrassing nationally televised performance at home. The 24 points were the most allowed by the Cardinals this season.

"This was a big test for us, and everyone saw how it went," Arizona coach Ken Whisenhunt said. "It was disappointing to say the least."

Quarterback John Skelton called the loss "embarrassing" and "humiliating."

Led by Smith's near-perfect precision passing, the 49ers methodically dominated from the start. He had the best completion percentage of his career, and he would have been perfect had Delanie Walker not dropped the ball when he was wide open on a crossing route in the first half.

A 10-play, 77-yard drive that consumed just over 6 minutes of the first quarter put San Francisco up 7-0. On third-and-goal from the 3, Smith threw a sidelines pass to Crabtree, who outfought Patrick Peterson for the ball and the touchdown.

A flurry missed tackles, most notably an open-field whiff by Sam Acho, helped Ted Ginn Jr. return a punt 35 yards to the Arizona 45 in the second quarter. Daryl Washington sacked Smith to help set up a third-and-23 from the Arizona 46. But Smith found Crabtree over the middle for 22 yards, just a yard shy of the first down. David Akers' 43 yard field goal made it 10-0 with 5:58 left in the half.

Crabtree beat Peterson again for San Francisco's second touchdown. Smith threw over the middle to the receiver, who caught the ball, then fooled Peterson with an inside move into the end zone to make it 17-0 with 1:41 left in the half. The 49ers drove 68 yards in eight plays, again overcoming a sack, this one by Calais Campbell, that made it second-and-goal from the 16. Smith threw 7 yards to Mario Manningham to set up the TD toss to Crabtree.

The Cardinals were booed off the field by the home crowd at the half.

Things didn't get any better for the home team in the third quarter. On third-and-9, Smith threw 30 yards to Crabtree, who evaded a host of tacklers. Then on third-and-8, Smith tossed a short pass to Moss, who sidestepped a series of would-be defenders all the way to the end zone, putting San Francisco ahead 24-0 with 7:27 left in the third quarter.

The Cardinals averted a shutout with Jay Feely's 28-yard field goal

John Skelton, making his second start since Kevin Kolb went down with rib injuries, completed 32 of 52 passes for 290 yards, often overthrowing receivers. The Cardinals rushed for just 7 yards in nine attempts against the 49ers, who entered the game as the No. 1-ranked defense in the NFL, No. 2 against the run.

Arizona's final possession ended when Larry Fitzgerald was stopped at the 1.

Notes: The roof was open at University of Phoenix Stadium, a rarity for Cardinals games. ... San Francisco C Daniel Kilgore left the game in the first quarter with a concussion. ... Washington had two sacks, giving him eight for the season. ... In its two nationally televised night appearances this season, against St. Louis on a Thursday and San Francisco on Monday, Arizona was outscored 41-6. ... The 49ers improved to 3-1 on the road, winning their last two away from home by a combined 55-3. ... Only Jerry Rice (208), Emmitt Smith (175) and LaDainian Tomlinson (162) have more touchdowns than Moss. ... Justin Smith had two of San Francisco's four sacks. ... The 49ers have a bye this week. The Cardinals are at Green Bay on Sunday.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

___

Follow Bob Baum at www.twitter.com/Thebaumerphx

Source: http://news.yahoo.com/smith-almost-perfect-49ers-flatten-arizona-24-3-034121129--spt.html

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How to encourage innovation | ***** - SelfImprovement.ch | betiragrie

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Source: http://vince68.typepad.com/blog/2012/10/how-to-encourage-innovation-selfimprovementch-betiragrie.html

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iPad Mini Beats Surface to the Launch

Apple has announced a special press event for October 23 -- three days before Microsoft's impending launch of Windows 8 and the Surface tablet. It's widely believed that Cupertino will launch the much-anticipated iPad mini on that date. An iPad mini "will definitely be disruptive to the 7-inch media tablet space," said Rhoda Alexander, a research director at IHS iSuppli.

Source: http://ectnews.com.feedsportal.com/c/34520/f/632000/s/249395ce/l/0L0Stechnewsworld0N0Crsstory0C7640A60Bhtml/story01.htm

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Chevy says 2014 Corvette will debut in January

DETROIT (Reuters) - An all-new 2014 Chevrolet Corvette, the seventh generation of the uniquely American sports car in six decades, will make its debut January 13 on the eve of the North American International Auto Show, General Motors' Chevrolet brand said on Thursday.

Eagerly awaited by auto enthusiasts, the new Corvette - dubbed C7 by the faithful but known to GM and its suppliers by the development code Y1XX - is widely expected to have a radically restyled exterior, a more upscale interior, a lighter chassis, and a more efficient engine and transmission.

There will be a 6-month gap between the 2014 Corvette new C7 and the current C6 version, a Chevrolet spokesman said in an email. GM will stop building the 2013 model in early February, and is due to start producing the 2014 model in volume in July.

The first of the new C7 Corvettes is expected to roll off the line in Bowling Green on June 30 - 60 years to the day that the first 1953 model was produced, according to two suppliers familiar with the automaker's plans but are not authorized to speak on behalf of GM.

The C7's formal unveiling in mid-January also marks the anniversary of the Corvette's debut in January 1953 as a GM Motorama "dream car" concept in New York. Since then, GM has built and sold more than 1.5 million Corvettes, although annual sales have slowed in recent years as higher vehicle prices, rising fuel and insurance costs, and growing competition from Europe and Asia have eroded its once fiercely loyal owner base.

To rekindle interest in the Corvette, especially among younger, affluent buyers who tend to favor imported brands, Chevrolet has completely overhauled the car for the first time since the sixth-generation model was launched in July 2004.

The result, according to chief engineer Tadge Juechter, is "a truly all-new Corvette. There are only two carryover parts from the C6 used in the C7 - the cabin air filter and the rear latch for the removable roof panel."

Chevrolet even has redesigned the Corvette's familiar crossed-flags emblem for the 2014 model.

Other significant upgrades, according to the supplier sources, include a smaller, lighter aluminum V8 engine displacing around 5.5 liters, advanced features such as direction injection, cylinder cutoff and variable valve timing, and a new seven-speed manual transmission for improved fuel economy.

Prices, due to be announced next summer, are expected to range from just under $55,000 for the base model to nearly $120,000 for the top-of-the-line Corvette ZR1.

Chevrolet said dealers will continue to take orders for the current model until December. (Reporting By Paul Lienert in Detroit; Editing by Richard Chang)

Source: http://news.yahoo.com/chevy-says-2014-corvette-debut-january-140219481--sector.html

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The Shabby Nest: An Autumn-Inspired Living Room~

I had the opportunity recently to work on a living room e-design for a dear friend of mine from Massachusetts.? She and her family had recently relocated to Wisconsin, and had purchased a new home which was bigger than the one they had in Massachusetts.

This left her with a fun dilemma (well, fun to me, anyway).? She didn't have enough furniture to fill the new house.? She and her husband often entertain business colleagues, and she wanted to create a living room which would be a great place for conversation and which would truly incorporate who their family is.?? To make sure that the room was a reflection?of their family, we started by picking out some art that reminded them of their home in Massachusetts...a beautiful photograph of the Quabbin Reservoir in the autumn.

She also requested that I incorporate the color red, since she has an open floor plan, and red is a color that she already has in her kitchen and dining room.? Because I was going to use red in the color scheme and the photo we chose showcased the autumn colors of New England, a fall-hued palette seemed like a natural choice.

Pretty golds, browns, reds (of course) and a touch of green make this living room a cozy, comfortable place to be and to entertain.? And the best part, is when I was finished coming up with the plan, I could really see my friend living in the space.? And her resulting email to?me confirmed that this is exactly what she would have designed, if she could have done it herself.? To a designer, there is really no greater compliment than that!

If you have a design dilemma that you'd like help with, I'm your gal.? You can check out my e-design packages here.?

Want to see other e-design moodboards?? Check out these posts...

Out of respect for my paying clients, I do not post e-design sources on my blog.? Thanks for understanding.

Source: http://shabbynest.blogspot.com/2012/10/an-autumn-inspired-living-room.html

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What Social Networks Can Do For Your Small Business | Liz Strauss ...

October 17, 2012

Liz published this at 7:20 am

by
Alex Summers

If you?re a small business owner, you can use social media networks to establish your company?s presence on the Internet. These tools can help you keep in touch with current customers and help you find new clients. Your business must adapt to the online marketplace to take advantage of the Internet.

How to Connect With Your Audience

If you already have a website for your business, you can improve it by adding a blog. A blog allows your regular visitors to easily see your latest news and updates. Additionally, visitors can use the comment portion of your blog to give you instant feedback. Be sure to save copies of your blog files to an external hard drive. This will help you get your blog running again after a server failure or other technological catastrophe.

Social networks give you another way to directly communicate with your customers. Twitter and other similar networks allow you to strike up a conversation with a customer through a series of short messages. Your customers can use these networks to get help with your products or services.

Many Internet users today have their own Facebook account. Creating a Facebook account for your business gives your customers a new way to reach you. Your Facebook profile can share important information about your company, including contact details and special deals.

The Benefits

Using these tools helps you to establish yourself on the Internet. Today?s Internet users expect their favorite businesses to have an online presence. Many customers want to have the ability to talk to a company representative when they need help with a product. Some consumers will forget about a company that lacks an online presence.

Social networks also provide you with easy ways to advertise your business for free. Through Facebook and Twitter, you can talk to thousands of people at no charge. You can use these tools to tell people more about your business and your story.

Additionally, when you communicate with a regular customer through these networks, your potential customers can see how you publicly handle your business. Through positive online interactions, you can help generate buzz for your company. You may even attract new customers just from responding quickly to your current clients.

Social networking tools can help your small business find a place in the modern business world. Learning how to use these tools effectively will take time, but your company may find new customers due to your efforts.

Author?s Bio:
Alex is a blogger, freelance writer and recent college graduate. She currently performs market research for an online marketing firm when she is not contributing her own thoughts and observations to the online community.

Filed under Marketing /Sales / Social Media, Successful Blog | No Comments ?

Source: http://www.successful-blog.com/1/what-social-networks-can-do-for-your-small-business/

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Ryan to Biden: ?I know you?re under duress to make up for lost ground?

As the vice presidential debate shifted to domestic issues, the vice presidential candidates were asked to weigh in on Medicare.

"They got caught with their hands in the cookie jar, robbing Medicare to pay for Obamacare," Ryan said of his assertion that seniors would lose Medicare access under the president's plan.

Biden continued to interrupt Ryan, attempting to argue with his assertions. "That's not true, more people signed up [for Medicare]," Biden said.

Ryan then addressed the first presidential debate, taking an ironic verbal shot at Biden. "I know you're under a lot of duress to make up for lost ground," Ryan said.

"Well, don't take up all the four minutes, then," Biden shot back.

Though for the record, at the time of the exchange, Biden had been speaking for over two minutes longer than Ryan in total debate time.

When it was officially Biden's turn again, he chose to address the debate cameras directly.

"Seniors are not denied choices," Biden said. "All you seniors out there, have you been denied choices?"

Source: http://news.yahoo.com/blogs/ticket/ryan-biden-know-under-lot-duress-lost-ground-014741509--election.html

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First whole genome sequencing of multiple pancreatic cancer patients has been outlined

ScienceDaily (Oct. 10, 2012) ? Whole genome sequencing -- spelling out all 3 billion letters in the human genome -- "is an obvious and powerful method for advancing our understanding of pancreatic cancer," according to a new study from TGen, Mayo Clinic and Scottsdale Healthcare published October 10.

The Translational Genomics Research Institute (TGen) demonstrated that the use of WGS "represents a compelling solution to obtaining detailed molecular information on tumor biopsies in order to provide guidance for therapeutic selection," concluded the study published by the journal PLOS ONE.

Examining three patients, the study spelled out the DNA of normal cells and compared that to the DNA of cells from biopsies of pancreatic adenocarcinoma (PAC), which makes up 95 percent of all pancreatic cancer tumors. Pancreatic cancer is the fourth leading cause of cancer death in the U.S.

Using next-generation sequencing, the study generated an average of 132 billion mappable bases, or data points, for each patient, resulting in the identification of 142 cellular genetic coding events, including mutations, insertions and deletions, and chromosomal copy number variants.

"This study is the first to report whole genome sequencing findings in paired tumor/normal samples collected from (three) separate PAC patients," said the report, which also was compiled with the collaboration of Mayo Clinic in Arizona, Arizona State University, and the Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, which is a partnership between TGen and Scottsdale Healthcare.

In all three case studies, the report found multiple potential therapeutic targets, highlighting the need to study the full spectrum of the genome and re-emphasizing the need to develop multiple avenues of therapeutics to match the specific medical challenges of each patient.

"Cancer, and specifically here pancreatic cancer, is a highly complex disease that ultimately will require a variety of treatment methods to control, and ultimately to cure," said Dr. Daniel Von Hoff, TGen's Physician-In-Chief, and Chief Scientific Officer for the Virginia G. Piper Cancer Center at Scottsdale Healthcare.

"This study shows that, as we continue to generate more information by sequencing the whole genomes of patients, we will continue to discover -- with ever more confidence -- the specific mechanisms that cause this cancer," said Dr. Von Hoff, one of the study's senior authors and one of the world's leading authorities on pancreatic cancer.

"We are very pleased to be working together with TGen in bringing hope and state of the art therapy to our patients at the Mayo Clinic Comprehensive Cancer Center," said Keith Stewart, M.B., Dean of Research at Mayo Clinic in Arizona, and the study's other senior author.

In the case of Patient 1, for example, genes previously associated with PAC were identified, including BRCA2, TP53, CDKN2A, MYC, SMAD4 and KRAS. But the study also made new discoveries. "Although BRCA2 mutations have been identified in PAC, the deletion we identify here in exon 10 of BRCA2 has not been previously reported," the study said.

Multiple therapeutics based on these findings were applied to Patient 1, who initially "showed a complete response,'' but developed drug resistance after six months.

"The BRCA2 deletion is likely the driving mutation in this patient as the loss of DNA repair functions permits the occurrence of mutations," the study said. "This finding and association provides evidence of the utility of performing whole genome analysis of patients in order to identify less common mutations that may be relevant for therapeutic selection."

WGS for Patient 2 and Patient 3 also uncovered multiple potential therapeutic targets through the identification of mutations and copy-number changes. In addition, RNA sequencing, or whole transcriptome analysis, of Patient 2 and Patient 3 revealed gene expression data that provided more information about likely affected biological processes.

Cellular pathway analysis of all sequencing data was also performed to identify processes that may be the most heavily impacted by cellular and gene expression alterations.

"As we continue to sequence patients, we will acquire a better understanding of the compendium of events that have a role in the disease, and strengthen our knowledge base for identifying and developing improved therapeutics," said Winnie Liang, Ph.D., Assistant Director of TGen's Collaborative Sequencing Center and one of the co-lead authors of the study.

"This study has demonstrated the feasibility of applying genome sequencing approaches toward eventual personalization and precision of therapy for patients with pancreatic cancer," said Dr. Mitesh Borad, hematologist/oncologist at Mayo Clinic in Arizona and co-author of the study. "Current studies are focusing on application of this approach in the clinical setting in a real time fashion."

Co-author Dr. Michael Demeure, Clinical Professor of TGen's Rare Cancer Unit and Scientific Director of the Endocrine and Rare Tumors Program at the Virginia G. Piper Cancer Center at Scottsdale Healthcare, said, "Whole genome sequencing provides us with the genetic blueprint and knowledge that is needed to crack the complex mysteries surrounding pancreatic cancer. For rare cancers where the data pool is relatively small, the potential for progress is particularly encouraging."

This groundbreaking study -- Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing -- was funded by: the National Foundation for Cancer Research, the Randy Pausch Scholarship Fund, and the Seena Magowitz Foundation. Additional support was provided by the Mayo Clinic Comprehensive Cancer Center, the U.S. Department of Health and Human Services, and supercomputing resources funded by the National Institutes of Health.

"This study represents a major step forward in the quest to find a cure for this cancer, which took the life of my mother, Seena. We are working harder than ever with TGen and others to continue this fight," said Roger Magowitz, President and co-founder of the Seena Magowitz Foundation.

"Whole genome sequencing is a new approach toward finding better treatments and to making these treatments available to cancer patients who need them now. We cannot emphasize enough the need for this kind of research," said Franklin C. Salisbury Jr., President of the NFCR.

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The above story is reprinted from materials provided by The Translational Genomics Research Institute.

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---

Journal Reference:

1. Liang WS, Craig DW, Carpten J, Borad MJ, Demeure MJ, et al. Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing. PLoS ONE, 2012 DOI: 10.1371/journal.pone.0043192

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/uLATjNrLktQ/121010172130.htm

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Toyota to recall 7.4 million vehicles over power window glitch

TOKYO (Reuters) - Toyota Motor Corp said it would recall more than 7.4 million vehicles worldwide as a faulty power window switch was a potential fire hazard, the latest in a series of setbacks that have dented the reputation of Japan's biggest automaker.

The voluntary move is the biggest single recall since Ford pulled 8 million vehicles off the road in 1996 to replace defective ignition switches that could have caused engine fires.

Toyota has battled its way back from multiple difficulties since 2008, including a series of recalls involving more than 10 million of its vehicles in 2009-11, and crippled supply chains from last year's earthquake and tsunami in Japan and floods in Thailand. It posted its biggest quarterly operating profit in four years in April-June.

The firm regained its crown as the world's best-selling automaker in the first half year and expects to sell 9.76 million cars and light trucks globally this year, including the Daihatsu and Hino brands.

More recently, though, Toyota - and other Japanese brands - have seen sales plummet in China, the world's biggest autos market, as a result of protests in a simmering Sino-Japanese territorial dispute. Toyota said on Tuesday that its China sales fell 48.9 percent year-on-year in September. Sales in China account for about 12 percent of its total.

QUICK FIX

The recall, intended to fix a malfunctioning power window switch on the driver's side, primarily affects cars in the United States, China and Europe.

Toyota's main rivals in the U.S. include Ford and General Motors Co , while in China they include Volkswagen AG , Hyundai Motor Co and Nissan Motor Co Ltd , and in Europe, Hyundai and Nissan.

The recall will include some Yaris and Corolla models, with repairs taking about 40 minutes, the company said.

"The process to repair (the power window switch) is not an extensive one," spokeswoman Monika Saito said, adding that it would involve putting heat-resistant grease on the switches, or exchanging them.

Toyota declined to say how much the recall would cost, or what impact it may have on future earnings.

Koichi Sugimoto, senior analyst at BNP Paribas Securities in Tokyo, estimated the recall could cost at least 10 billion yen ($128 million).

"Of course, 7 million vehicles is a huge number, but it's probably not going to be like last time when customers in the United States avoided buying Toyota cars. This sounds like a completely different scale from then," he said.

GLOBAL SCALE

The recall will include 2.47 million vehicles in the United States, 1.4 million in China and 1.39 million in Europe, the company said.

No accidents, injuries or deaths have been reported as a result of the problem, though there is a possibility the malfunctioning switches could emit smoke, Saito said. Toyota's U.S. news release said the problem could lead to fire if commercially available lubricants were used on the switch.

Toyota will take in for repair about 459,300 vehicles in Japan, including the Vitz model, produced between 2006 and 2008.

The firm is also recalling 650,000 vehicles in Australia and Asia, 490,000 in the Near and Middle East, 240,000 in Canada and 330,000 elsewhere, said Shino Yamada, another spokeswoman for Toyota.

The vehicles recalled outside Japan include some models of the Yaris, Vios, Corolla, Matrix, Auris, Camry, RAV4, Highlander, Tundra, Sequoia, xB and xD produced between 2005 and 2010.

The first time the problem was reported was in September 2008 in the United States, Saito said.

Shares in Toyota ended down 1.9 percent, in line with the broader Nikkei index <.n225>.

(Additional reporting by Kentaro Sugiyama; Editing by Daniel Magnowski and Ian Geoghegan)

Source: http://news.yahoo.com/toyota-recall-7-4-million-vehicles-globally-power-060902894--sector.html

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New Polls (talking-points-memo)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/254682329?client_source=feed&format=rss

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Germany says Merkel visit to Athens does not mean aid for Greece

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Payday Loan Lender - Your Economic Company | Poodle

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Romney vs Obama vs debate: Was the president drugged by a right-wing doctor?

Sunday, debate guru Brett O'Donnell reviewed President Obama's debate performance on Power Play with Chris Wallace. O'Donnell noted that during the debate the president seemed strangely unfocused, even oblique, and exhibited some genuinely bizarre body language. O'Donnell's trained eye noted Obama's avoidance went further than merely keeping his head down.

O'Donnell pointed out that standing behind a podium which "canted right," Obama deviated from this natural angle by physically turning his entire body to the left. Visually, Obama appeared reluctant to face the moderator, Jim Lehrer, the cameras or Mitt Romney. The result was Obama appeared to show what many would describe as a "cold shoulder" to the debate process.

While O'Donnell used soft terms such as "appeared to lack focus" or "distracted," others are suggesting perhaps President Obama was on drugs or medication. Immediately following the debate, the New York Times described Obama as "President Prozac."

A Lubbock, Texas news article, remarked that "Obama appeared to be fatigued and detached" and posited that a combination of both arrogance and medication or drugs had "brought him down." Saturday, an Obama apologist inferred the right-wing had sabotaged the president, asking, "Were medication errors involved in Obama's debate performance? Is a right-leaning MD behind the debacle, maybe?"

Obama has an admitted history of drug abuse and given his bewildering debate performance, speculation may not be so far-fetched; although, any suggestion that Obama might actually employ a right-wing physician should probably be pooh-poohed. Regarding the questions about whether Obama was "simply exhausted" or had "taken some medications or drugs in an attempt to improve his concentration, to boost his confidence, and possibly even to calm his nerves," it's true,"we will probably never know."

In the past, Democrats quickly claimed that Representative Hank Johnson was a victim of medication when he expressed his fears that "Guam would tip over from soldiers' extra weight," if 8000 Marines and their families moved to the island. At this time, neither drugs nor prescription medication has been mentioned by the Obama team as a reason that Mitt Romney reduced Obama to what some consider "mince-meat" in the debate.

While conservatives were pointing to Jim Lehrer's warning, "Mr. President, your time is up," as prophetic, critics were quick to place the blame on Lehrer, who is perhaps the most well-seasoned debate moderator known. They are claiming his hands-off approach failed to allow Obama to shine. To the contrary, the transcript of the debate spotlights several instances when Lehrer attempted to cue the president on his message, even to the point of providing him with actual phrases that Obama could use.

For instance, Lehrer clearly cued the president by saying, "Mr. President, you're saying in order to get it, the job done, it's got to be balanced." Obama responded, "If we're serious, we've got to take a balanced, responsible approach." In this case, Obama basically repeated Lehrer's helpful cue and then continued to expand upon it somewhat.

From this National Public Radio excerpt, it's readily apparent that though Lehrer did try handily to help Obama stay on track; he wasn't always successful. This example shows how Obama failed to focus and missed an opportunity that Lehrer tried so hard to provide him. Instead, Obama merely repeated what Lehrer said and allowed his opportunity to move to Romney:

"Mr. Lehrer: Mr. President.

President Obama: Well, we've had this discussion before.

Mr. Lehrer: No, about the idea that in order to reduce the deficit there has to be revenue in addition to cuts.

President Obama: There has to be revenue in addition to cuts. Now, Governor Romney has ruled out revenue. He's, he's ruled out revenue."

Obviously, there are no flattering reasons to explain why Obama was soundly trounced. Even for someone who is reaching desperately for a reason to excuse Obama's inability to defend his leadership during his term or to promote his leadership going forward, an evil right-wing doctor is quite a stretch. Drugs, either illegal or medicinal, aren't so easily dismissed.

Comedy star Bill Maher was one of the dismayed Obama donors who suggested the president was, indeed, on drugs, saying with despair, ?He looked tired. He had trouble getting his answers out. It looked like he took my million and spent it all on weed.?

In the meantime, the Obama team is ironically looking to an unlikely savior, Joe Biden, to rescue Obama in this week's debate against his GOP rival, Paul Ryan. Biden is gaffe-prone and not only called "jobs" a three-letter word, he recently claimed the middle class has been "buried" for the past four years." Overnight the presidential debates, once considered almost an after-thought that are seldom political game-changers, have morphed into must-see political events.

Source: http://www.examiner.com/article/romney-vs-obama-vs-debate-was-the-president-drugged-by-a-right-wing-doctor

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ThinkProgress Gets Hit by Google's Red Screen of Doom

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White House widens covert war in North Africa

FILE -In this June 27, 2012 file photo, House Oversight and Government Reform Committee Chairman Rep. Darrell Issa, R-Calif. speaks on Capitol Hill in Washington. Leaders of a House committee said Tuesday that U.S. diplomats in Libya made repeated requests for increased security for the consulate in Benghazi and were turned down by officials in Washington. In a letter to Secretary of State Hillary Rodham Clinton, Chairman Darrell Issa and Rep. Jason Chaffetz said their information came from "individuals with direct knowledge of events in Libya." (AP Photo/J. Scott Applewhite, File)

FILE -In this June 27, 2012 file photo, House Oversight and Government Reform Committee Chairman Rep. Darrell Issa, R-Calif. speaks on Capitol Hill in Washington. Leaders of a House committee said Tuesday that U.S. diplomats in Libya made repeated requests for increased security for the consulate in Benghazi and were turned down by officials in Washington. In a letter to Secretary of State Hillary Rodham Clinton, Chairman Darrell Issa and Rep. Jason Chaffetz said their information came from "individuals with direct knowledge of events in Libya." (AP Photo/J. Scott Applewhite, File)

FILE - In this July 19, 2011 file photo, Rep. Jason Chaffetz, R-Utah speaks on Capitol Hill in Washington. Leaders of a House committee said Tuesday that U.S. diplomats in Libya made repeated requests for increased security for the consulate in Benghazi and were turned down by officials in Washington. In a letter to Secretary of State Hillary Rodham Clinton, Chairman Darrell Issa and Rep. Jason Chaffetz said their information came from "individuals with direct knowledge of events in Libya." (AP Photo/J. Scott Applewhite, File)

FILE - In this April 11, 2011 file photo, Ambassador Chris Stevens is seen in Benghazi, Libya. Leaders of a House committee said Tuesday that U.S. diplomats in Libya made repeated requests for increased security for the consulate in Benghazi and were turned down by officials in Washington. In a letter to Secretary of State Hillary Rodham Clinton, Chairman Darrell Issa and Rep. Jason Chaffetz said their information came from "individuals with direct knowledge of events in Libya." (AP Photo/Ben Curtis, File)

FILE - This Sept. 12, 2012 file photo shows a man walking through a room in the gutted U.S. consulate in Benghazi, Libya, after an attack that killed four Americans, including Ambassador Chris Stevens. Leaders of a House committee said Tuesday that U.S. diplomats in Libya made repeated requests for increased security for the consulate in Benghazi and were turned down by officials in Washington. In a letter to Secretary of State Hillary Rodham Clinton, Chairman Darrell Issa and Rep. Jason Chaffetz said their information came from "individuals with direct knowledge of events in Libya." (AP Photo/Ibrahim Alaguri, File)

WASHINGTON (AP) ? Small teams of U.S. special operations forces arrived at American embassies throughout North Africa to set up a new counterterrorist network months before militants killed the U.S. ambassador in Libya. But officials say the network was too new to stop the Benghazi attack.

The White House approved the plan a year ago, worried about a spread of al-Qaida after the killing of Osama bin Laden. But it moved slowly in order to win approval from U.S. ambassadors, intelligence and military chiefs and local governments. That's according to officials who spoke anonymously because they were not authorized to discuss the strategy publicly.

With U.S. elections nearing, Republicans say the White House failed to react aggressively to new al-Qaida threats before the attack and has failed to strike back quickly enough.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-10-02-US-North%20Africa-Terror/id-e7d60006ff794691bd484795d5d23210

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Mobile Master 8.5.4 Build 3591 | Blog Etam

Mobile Master is a mobile phone software tool for mobile phone management and SMS communication that can be used to exchange data between mobile phone and PC. Via cable, infrared, or Bluetooth, the system automatically detects the mobile phone and assigns it its own profile, making it possible to manage several phones without creating chaos with the data. An assistant helps with the settings. Even users with no prior knowledge can, for example, download their phones address book data to the PC with just a few mouse clicks. Edit and synchronize calendar entries (appointments and tasks). Send, read, archive SMS Note: the SMS Servant is included in the Mobile Master installation but requires an extra license. Logo-Editor, modify ring tone. Copy Station for transmitting your address book easily from one phone to the other. Mobile Master Agent: reach always the important functions easily and start e.g. Mobile Master automatically as soon as your mobile phone is connected to the PC.

One click synchronization solution for your mobile phone, edit all you phones data with the computer. Synchronization of contacts and the calendar, Many filter possibilities, AddIns for Outlook, Lotus Notes, Palm Desktop and Thunderbird
Mobile Master synchronizes or just copies all data with/to your mobile phone. Synchronize with: Outlook, Lotus Notes, Novell Groupwise, Palm Desktop, Thunderbird, Tobit David, Eudora, The Bat, Outlook Express, Google calendar, Windows contacts and calendar, iTunes
new cell phone: Mobile Master copies the phone/address book from your old to your new one regardless the manufacturer of the phones new phone number, appointment or note: type it in with your PC and send it easily to the cell phone.
Many import and export filters, e.g. one click to export to excel or open office. Can import e.g. vcf file with more than one contact and that has unicode format
Connection with the phone: serial or USB cable, infrared or Bluetooth, up to COM Port 300 supported.

Features:
Mobile Master is a handset manager to edit manually or synchronize automatically or on demand
Quick area for quick and easy access to the main functions
Comfortable editing of the phone book, calendar and note items
easy to use user interface
Setup Wizard for easy configuring
Copy files, music, photos
SMS send, archive
Copy the address book, calendar from one phone to another
At least one update per month for the phones and devices
Copy play lists from iTunes and WinAmp to the phone

Runs on /Synchronizes via: Windows 2000, Windows XP, Vista, Windows 7, Windows 8, including the 64 versions

Changes in Mobile Master 8.5.4 (01.10.2012):
* Now supported:
o Samsung Galaxy Ace Duos (GT-S6802)
* Fixed bugs/solved problems:
o Fixed problem with the upgrade license

Homepage http://www.mobile-master.com

Size: 21.4 MB

Download Final

Mobile Master 8.5.4 Build 3591, 2.2 out of 5 based on 24 ratings

Source: http://www.dedepurnama.com/2012/10/mobile-master-854-build-3591.html

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If you always type in long text strings, lighten your typing load with ...

If you always type in long text strings, lighten your typing load with AutoCorrect! Type your text string, for example,? ?a 501(c)3 organization.? Select it, then click on the File tab (or Office button) and Options (or Word Options). In the Proofing category, choose the first button, AutoCorrect. Type the shortcut you want to use going forward, like ?501-?. Now, just type 501-, and the longer phrase will appear. If you ever want to use 501- by itself, after the longer text string appears, just hit backspace. This will not prevent you from typing only 501.

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